Second seed Stefanos Tsitsipas lost 7-5, 6-4 to unseeded Slovenian Aljaz Bedene as upsets continued at the Rotterdam Open on Thursday.

Top seed Daniil Medvedev crashed out, losing to 104th-ranked Canadian Vasek Pospisil, who marched into the last 16 with a 6-4, 6-3 victory.

Tsitsipas earned five break points in the opening set but the Greek failed to convert any and Bedene won 11 points in a row to wrap up the set.

Bedene, ranked 52nd in the world, took an early lead in the second, breaking Tsitsipas at 1-1 before serving out to secure only his second win over a top-10 player and set up a quarter-final with Canadian teenager Felix Auger-Aliassime.

Although Bedene’s unforced error count was higher than his opponent’s, the 30-year-old fired 20 winners — eight more than the world number six.

Auger-Aliassime advanced with a 6-4 6-2 victory over Bulgarian Grigor Dimitrov in 77 minutes.

Fourth seed David Goffin was eliminated in straight sets by Jannik Sinner, losing 7-6(7) 7-5 to the unseeded Italian.

Russian Andrey Rublev continued his impressive form with a 7-5 6-3 victory over Alexander Bublik to extend his win record in 2020 to 13-1.

World number five Medvedev, long-touted as one of the most likely of the new generation of players to win a Grand Slam, saw his Rotterdam challenge ended in just 68 minutes by Pospisil.

The 29-year-old Canadian, who continues a fine run of form having reached the final at the Open Sud de France in Montpellier last week, managed to save five of six break points while converting three of his own en route to a huge upset.

France’s Gael Monfils started his Rotterdam title defence with a convincing 6-3, 6-2 victory over Portugal’s Joao Sousa.

Monfils who beat Pospisil in the final to win in Montpellier last week, needed only 70 minutes to dispatch his Portuguese opponent, firing five aces and converting four break points.

The 33-year-old Frenchman, who is looking to become the first player to win back-to-back Rotterdam titles since Sweden’s Robin Soderling in 2011, next faces compatriot Gilles Simon who beat Mikhail Kukushkin 7-6 (3), 3-6, 6-3. “It’s never easy to come back after a win,” Monfils said. “But I have great memories from last year.”

In an all-Spanish showdown, Pablo Carreno Busta beat sixth seed Roberto Bautista Agut 6-4, 2-6, 7-6 (4) to qualify for the quarterfinal after a battle lasting nearly two-and-a-half hours. Carreno Busta fired 11 aces and saved seven break points to advance at his higher-ranked compatriot’s expense.